Klean Probiotic™

Oral supplements of live, beneficial intestinal micro-organisms for nutritional health and well-being are known as probiotics. Probiotic dietary lactobacilli and bifidobacterium colonize the intestinal tract. The composition of the intestinal microflora is dynamic and constantly changing. If harmful microorganisms proliferate, the equilibrium is disturbed, and it becomes difficult even for indigenous bacteria to maintain their necessary territory to colonize the intestine. Antibiotics tend to kill off both beneficial and harmful bacteria and thus may also disturb the normal, healthy balance of intestinal microorganisms.

Various intestinal conditions can compromise the immune system and lower the amounts of healthy intestinal microflora. When potent probiotic supplements, such as Klean Probiotic™, are supplied regularly, chances are greatly increased for establishing and maintaining a healthy population of beneficial intestinal microorganisms†. Once established, a normal intestinal microflora rich in lactobacilli creates acidic conditions that are unfavorable for the settlement of pathogenic microorganisms. Clinical trials also suggest that the exposure to microbes through the gastrointestinal tract powerfully shapes immune function.

The ability for probiotic cultures to survive stomach acidity and pH is no longer of concern. The live cultures in Klean Probiotic™ have been studied in vitro to be extremely resistant to low stomach pH and bile acids in the duodenum, and also show increased binding to human intestinal walls and protective effects of intestinal colonization. Prebiotics (fructooligosaccharides) are carbohydrates that have short molecular chains. They function as non-digestible ingredients that can positively affect selected groups of beneficial intestinal microflora, such as lactobacillus. While probiotics merely add beneficial microflora, prebiotics affect the intestinal environment so that beneficial colonies of microflora can flourish. By aiding the beneficial microflora’s survival, unwanted microflora can have a decreased chance of survival. Several studies in animals and humans have shown positive effects of probiotics and prebiotics on mineral absorption and metabolism and bone composition due to improved gut functioning and multiple other factors.†

Klean Probiotic™ is tested and certified by the NSF Certified for Sport® program, which was created to meet the growing demands of athletes, coaches and healthcare professionals to certify that sports supplements are safe and completely free from banned substances. Every product that carries the NSF Certified for Sport® mark has undergone stringent laboratory testing to confirm content, purity and compliance.

INDICATIONS Klean Probiotic™ capsules may be a useful dietary supplement for athletes who wish to support their immune system and intestinal microflora with potent amounts of beneficial microorganisms.

REFERENCES

Cebra JJ. Influences of microbiota on intestinal immune system development. Am J Clin Nutr 1999;69:1046S-1051S. Collins MD, Gibson GR. Probiotics, prebiotics, and synbiotics: approaches for modulating the microbial ecology of the gut. Am J Clin Nutr 1999;69:1052S-1057S. De Vrese M, Schrezenmeir J. Probiotics, prebiotics, and synbiotics. Adv Biochem Eng Biotechnol. 2008;111:1-66. Gibson GR. Dietary modulation of the human gut microflora using prebiotics. Br J Nutr 1998;80:S209-12. H.Lee, K.M.Shahani. Inhibitory Effect of Lactobacillus Acidophilus on transformation of bile acids by human fecal microflora. Microbiologie-Aliments-Nutrition.1995;13;241-247. Murthy M, Venkitanarayan K.S., Rangavajhyala N and K.M. Shahani. Delineation of beneficial characteristics of effective probiotics. J. Am. Nutr. Assoc, 2000 3(2), 38-43 Scholz-Ahrens KE, Ade P, Marten B, Weber P, Timm W, Açil Y, Glüer CC, Schrezenmeir J. Prebiotics, probiotics, and synbiotics affect mineral absorption, bone mineral content, and bone structure. J Nutr. 2007 Mar;137