Suggested Use: Take 1 capsule one to three times daily, or as recommended by your healthcare practitioner.
Alpha-Glycosyl Isoquercitrin -
Alpha-Glycosyl Isoquercitrin provides all the benefits of quercetin with better absorption.† Quercetin is an important flavonoid that provides antioxidant protection at the cellular level.
The Antioxidant Protection of Quercetin
Quercetin is an important flavonoid that provides antioxidant protection at the cellular level. It has demonstrated several beneficial effects on the body:
Scavenges free radicals, promotes DNA integrity, and supports cellular regulation†
Has been studied for its support of healthy glutathione levels†
Inhibits glucose absorption in the intestines†
Supports healthy histamine release and immune response†
Exclusive, Bioavailable Quercetin
Alpha-Glycosyl Isoquercitrin—an Integrative TherapeuticsTM exclusive—delivers all the benefits of quercetin with better absorption and improved bioavailability.†
Enhances cellular antioxidant defenses†
Supports cardiovascular health†
Modulates the body’s immune-response mechanisms†
Alpha-Glycosyl Isoquercitrin has 3 times the bioavailability of isoquercetin and nearly 18 times the bioavailability of quercetin aglycone. Because it is actively and rapidly absorbed, Alpha-Glycosyl Isoquercitrin reaches peak plasma levels in 15 minutes!†
Quercetin as a Foundational Flavonoidz
Quercetin possesses potent antioxidant properties to scavenge free radicals, promote DNA integrity, and support cellular regulation.* Quercetin has also been studied for its support of healthy glutathione levels.*
Quercetin is a foundational structure of many flavonoids, including rutin, hesperidin, and isoquercitrin. The quercetin ring structure also occurs as part of larger flavonoid molecules, such as hyperosides in St. Johns wort or flavone glycosides in Ginkgo. Quercetin aglycone is the type of quercetin most typically used in supplements because it is the easiest to produce from rutin. However, this form of quercetin rarely occurs in nature and is not actively absorbed (but rather is passively diffused) at the absorptive surfaces in the small intestine.
Supplemental quercetin (quercetin aglycone) is not actively absorbed. Its absorption occurs through the small intestine by the slower, less efficient process of passive diffusion.
Quercetin Glucosides, The Predominant Form
In nature, quercetin occurs predominantly in the glucoside form, usually with the glucoside chain at the 3' or 4'position. Apples and onions are among the richest dietary sources of quercetin glucosides, notably the quercetin-3-monoglucosides, isoquercitrin, and isoquercetin.
Isoquercitrin and Isoquercetin
Isoquercitrin and isoquercetin are terms that are sometimes used interchangeably, even by specialists, because the two molecules are very similar in structure. The difference between them is that isoquercitrin has a glucofuranose ring structure, whereas isoquercetin has a glucopyranose ring structure. Functionally, the two molecules are nearly indistinguishable. These quercetin glucosides have been shown to be more highly bioavailable than the smaller quercetin aglycone or the larger quercetin glycosides such as rutin (quercetin rutinoside).1 Quercetin glucosides are also more quickly absorbed, at approximately double the rate of quercetin, and up to ten times more quickly than rutin.*
Quercetin Absorption
Quercetin glucosides, such as isoquercitrin and isoquercetin, have been shown to be much more bioavailable and more quickly absorbed than quercetin aglycone or quercetin glycosides, such as rutin (quercetin rutinoside).1-5
The glucose moiety of isoquercitrin and isoquercetin speeds the molecules' uptake and transformation into quercetin.
Enzymes and active transport mechanisms in the cells lining the small intestine (enterocytes) interact with the glucose moiety of the isoquercitrin and isoquercetin molecules, speeding their uptake and transformation into quercetin.1,2 Without this glucose moiety, absorption of quercetin through the small intestine is by the slower, less efficient process of passive diffusion.1,5 Isoquercitrin and isoquercetin therefore provide quercetin, with all its benefits, in a more bioavailable form.3-7
The bioavailability of isoquercitrin can be further enhanced through an enzymatic process.
Alpha-Glycosyl Isoquercitrin Has Superior Bioavailability
Alpha-Glycosyl Isoquercitrin (also known as enzymatically-modified isoquercitrin) is a proprietary mixture of quercetin monoglucoside and its alpha-oligoglucosides, consisting mainly of isoquercitrin and its alpha-glucosyl derivatives with 1-7 of additional linear glucose moieties. Animal research has found that Alpha-Glycosyl Isoquercitrin has far greater bioavailability than quercetin aglycone and even higher than quercetin glucosides.,8,9
Oral bioavailability of quercetins is influenced by their water solubility. Quercetin aglycone is relatively insoluble in water, limiting its usefulness as a dietary supplement. Isoquercitrin and isoquercetin are somewhat more soluble. Researchers have found that water solubility of flavonoids can be further enhanced by enzymatic modification. This has been demonstrated, for example, with the flavonoid hesperidin.10,11
Bioavailability of quercetins is influenced by their water solubility. Alpha-Glycosyl Isoquercitrin is more soluble than isoquercitrin, isoquercetin, and quercetin aglycone.
Glycosyl conjugates of isoquercitrin have also been achieved via enzyme-based processes. These have been found to be far more soluble than either quercetin aglycone or quercetin glucosides, and are thus more readily hydrolyzed by intestinal epithelial enzymes, such as lactase-phrolizin hydrolase and mucosal maltase-glucoamylase.12
Bioavailability of quercetin, isoquercetin and Alpha-Glycosyl Isoquercitrin was compared directly in an animal model. Bioavailability was found to be 2% for quercetin, 12% for isoquercetin, and 35% for Alpha-Glycosyl Isoquercitrin.8
How Does It Work?
Because Alpha-Glycosyl Isoquercitrin is transformed to quercetin in the body, it provides all the health benefits of quercetin in a more bioavailable form.* Quercetin has been shown to prevent the production of free radicals, including reactive oxygen species (ROS) and reactive nitrogen species.*13 Research has shown that quercetin exhibits a broad range of support for the body's vascular responses to immune and exogenous stimuli.*14,15 Quercetin also helps the body maintain adequate glutathione levels during oxidative stress;16 supports a healthy immune response;17 inhibits xanthine oxidase activity and lipid peroxidation;18,19 supports healthy cellular regulation, DNA integrity, and normal cell apoptosis;20 and supports cardiovascular health.*21
Alpha-Glycosyl Isoquercitrin has been clinically studied.
Alpha-Glycosyl Isoquercitrin Supports Eye Comfort* Flavonoids are known to exert stabilizing effects on mast cells and thus support immune function. Researchers investigated the effects of Alpha-Glycosyl Isoquercitrin on immune response in two similarly designed double-blind studies.22,23 In both studies, subjects took 100 mg Alpha-Glycosyl Isoquercitrin or a placebo for 8 weeks. Subjective measures, activity (ADL) scores and the usage of drugs were recorded daily. Quality of life (QOL) scores were obtained every 4 weeks. In both studies, intake of Alpha-Glycosyl Isoquercitrin proved to be effective for support of ocular comfort.* Nasal airflow was unchanged.
Preclinical studies have also found significant hepatocellular health benefits of Alpha-Glycosyl Isoquercitrin in experimental animals, pointing the way towards future areas of human clinical research.*24-27
Alpha-Glycosyl Isoquercitrin is Generally Recognized as Safe (GRAS).
References
Arts IC, Sesink AL, Faassen-Peters M, Hollman PC. Br J Nutr 2004;91(6):841-7.
Boyer J, Brown D, Liu RH. Nutr J 2005;4:1
Morand C, Manach C, Crespy V, Remesy C. Free Radic Res 2000;33(5):667-76.
Olthof MR, Hollman PC, Vree TB, Katan MB. J Nutr 2000;130(5):1200-3.
Erlund I, Kosonen T, Alfthan G, et.al. Eur J Clin Pharmacol 2000;56:545-53.
Hollman PC, Bijsman MN, van Gameren Y, et. al. Free Radic Res 1999;31(6):569-73.
Day AJ, Williamson G. Br J Nutr 2001;86 Suppl 1:S105-10.
Makino T, Shimizu R, Kanemaru M, et al. Biol Pharm Bull 2009;32(12):2034-40.
Murota K, Matsuda N, Kashino Y et al. Arch Biochem Biophys 2010 Sep 1;501(1):91-7. Epub 2010 Jul 16.
Nielsen IL, Chee WS, Poulsen L, et al. J Nutr 2006 Feb;136(2):404-8.
Yamada M, Tanabe F, Arai N, et al. Biosci Biotechnol Biochem 2006 Jun;70(6):1386-94.
Emura K, Yokomizo A, Toyoshi T, Moriwaki M. J Nutr Sci Vitaminol (Tokyo) 2007;53(1):68-74. 13. Robak J, Gryglewski RJ. Biochem Pharmacol 1988 Mar 1;37(5):837-41.
Timofeev AA, Maksiutina NP, Topchiĭ DV, Voĭtenko GN, Balanda PP. Klin Khir 1990;(12):20-2. [Article in Russian]
Della Loggia R, Ragazzi E, Tubaro A, Fassina G, Vertua R. Pharmacol Res Commun 1988 Dec;20 Suppl 5:91-4.
Meyers KJ, Rudolf JL, Mitchell AE. J Agric Food Chem 2008 Feb 13;56(3):830-6. doi: 10.1021/jf072358l. Epub 2008 Jan 17.
Formica JV, Regelson W. Food Chem Toxicol 1995 Dec;33(12):1061-80.
Abbey EL, Rankin JW. Int J Sport Nutr Exerc Metab 2011 Apr;21(2):91-6.
Galvez J, de la Cruz JP, Zarzuelo A, et al. Gen Pharmacol 1994 Oct;25(6):1237-43.
Sakao K, Fujii M, Hou DX. Biosci Biotechnol Biochem 2009 Sep;73(9):2048-53. Epub 2009 Sep 7.
Edwards RL, Lyon T, Litwin SE, et. al. J Nutr 2007;137(11):2405-11.
Hirano T, Kawai M, Arimitsu J, et al. Allergol Int 2009 Sep;58(3):373-82. Epub 2009 May 25.
Kawai M, Hirano T, Arimitsu J, et al. Int Arch Allergy Immunol 2009;149(4):359-68. Epub 2009 Mar 17.
Morita R, Shimamoto K, Ishii Y, et al. Arch Toxicol 2011 Nov;85(11):1475-84. Epub 2011 Mar 29.
Yokohira M, Yamakawa K, Saoo K, et al. J Food Sci 2008;73(7):C561-8.
Shimada Y, Dewa Y, Ichimura R, et al. Toxicology 2010 Feb 9;268(3):213-8. Epub 2010 Jan 5.
Nishimura J, Saegusa Y, Dewa Y, et al. Arch Toxicol 2010 Feb;84(2):143-53. Epub 2009 Dec 22.
